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NUTRIGENOMICS

Nutrigenomics is at the intersection of nutrition and genetic expression, specifically how nutrients influence the genome and their relationship to health and wellness. The emergence of this field parallels the emergence of the broader field of precision healthcare, which tailors healthcare approaches to individuals based on their unique genetic makeup.

Pharmacogenomics, on the other hand, evaluates the metabolism, efficacy, and potential side effect of certain medications on a specific individual.In Australia, upon turning 18 years of age, everyone undergoes pharmacogenomic testing to determine determines whether one is a hyper- or hypo-metabolizer of particular medications, which in turn guides therapy by informing practitioners and patients whether a particular medication will or will not work on an individual.Sometimes if symptoms do not improve with hormone replacement therapy, performing Nutrigenomic and/or Pharmacogenomic testing can help determine whether they are causing your symptoms.

GX Sciences

GX Sciences is a premiere biotechnology company/laboratory based in Austin, TX. They offer the most comprehensive Nutrigenomic testing and interpretation platform available in the medical marketplace. Their customized software is specifically designed for medical providers to validate a patient’s specific nutritional needs, laboratory recommendations, medications, lifestyle recommendations and health precautions based on the patient’s individual DNA findings.

To obtain a sample, one only has to use a cheek swab to obtain cells from inside the mouth.  Each Nutrigenomic Panel is separately priced, and includes an in-depth report, and an appointment with Dr. Bornfleth to go over the results as early as two weeks later.  Over a million gene variants have been identified, most of which are SNPs (Single Nucleotide Polymorphisms).  GxSciences only analyzes 118 SNPs for which there are current therapeutic solutions.

One panel, the Functional Pro 7 Panel looks at 55 of these SNPs.  These 55 gene variants are analyzed to provide nutritional recommendations and health information based on scientific validation of a patient’s specific needs in these key areas: Methylation, Neurotransmitter Processing, Mitochondrial Function, Detoxification, Inflammatory Potential, and Health Precautions.

Below are the Nutrigenomic Panels performed by GXSciences and offered at Preventive Medicine of the Pacific.   The ones in bold are the main tests Dr. Bornfleth administers and goes over the results with you at a subsequent visit.  GxSciences performs additional Nutrigenomics Panels which can be considered on a case by case basis after discussion with Dr. Bornfleth.

Methylation Foundation Wellness Panel

For this Nutrigenomic Panel, 21 genes are analyzed for SNPs (single nucleotide polymorphisms). The report algorithms and customized software takes the patient’s genetic results and creates nutritional and lifestyle recommendations along with recommended lab work and health precautions based upon SNP results and clinical expertise. The built-in proprietary software takes out the guesswork and allows us to recommend the proper nutrition and health advisements safely by your DNA results.

WHO NEEDS THIS PANEL:

  • Everyone Seeking Better Health and Nutritional Guidance
  • Anyone with Dopamine Deficiency Symptoms
  • Anyone with Serotonin Deficiency Symptoms
  • Mood Disorders
  • Chronic Fatigue
  • Neurological Symptoms
  • Immune Disorders
  • Detoxification Weakness

Immune / Inflammatory / Autoimmune Panel

Inflammation is a proper response from the immune system. When something is present within the body that shouldn’t be, the immune system releases Interleukins (chemical messengers), which call on other immune cells to aid in removing the foreign substance. Inflammation becomes an issue when the regulatory mechanisms no longer properly regulate the release of Interleukins or Macrophages, the type of white blood cell that usually digests foreign substances.

WHO MAY BENEFIT FROM THIS PANEL

  • Asthma / Reactive Airway Disease
  • Eczema / Psoriasis
  • Severe Allergic Rhinitis
  • Granulomatous Disease
  • Autoimmune Disease
  • Rheumatoid Arthritis
  • Lupus
  • Sjogren’s
  • Chronic Dry Eyes
  • Hashimoto’s Thyroiditis
  • Chronic Fatigue Syndrome
  • Chronic Infections
  • Immune Weakness
  • Inflammatory Bowel Disease

DNA testing for inflammation has allowed us to learn which genetic differences, or SNPs, cause or influence problematic regulatory mechanisms. For example, if the CTLA4 gene is not functioning properly, T cells will continue to come to the inflamed area, causing chronic inflammation, which eventually causes long term damage to the area. The AOC1 gene mutation can speak to one’s poor ability to break down external histamine. Genetic testing for inflammation allows us to deal with unregulated inflammation by understanding where the problem lies.

THE INFLAMMATORY / AUTOIMMUNE PANEL COVERS 30 SNPS IN THE AREAS OF:

  • Cellular Inflammation
  • Autophagy Consideration
  • Environmental Inflammation
  • Skin and Joint Glutathione Status

Functional Pro 7 (55 SNP Analysis) Panel

Analyzes 55 gene variants to provide nutritional recommendations and health information based on scientific validation of a patient’s specific needs in these seven key areas: Methylation, Neurotransmitter Processing, Mitochondrial Function, Detoxification, External Inflammation, Internal Inflammation (Autophagy), and Health Precautions

WHY CHOOSE THE 55 SNP ANALYSIS NUTRIGENOMIC REPORT?

  • For patients who are overall healthy and desiring nutritional guidance
  • For patients with no significant family history of disease
  • For designing an overall health plan, fitness regimen or wellness optimization program
  • For children with healthy family histories
  • For basic problems with intestinal health and allergies

Gastrointestinal (GI) Panel

It has become increasingly clear over the past few years that gastrointestinal function and environment can have a tremendous impact on your overall health. The gastrointestinal system is complex and has a number of previously unknown roles in the stability of brain function and immune stabilization. This panel is designed to provide a scientifically validated system to indicate the need for a specific supplement or medication based on an individual’s genetic profile.There is a major immunological presence around the gut. As the GI tract introduces only foreign organisms (like bacteria and viruses), the gut is a likely place for contamination. To combat the inherent risk, 70% of the immune system surrounds the gut to protect the whole body from getting sick. Since the support of brain function, immune stabilization, and digestive process are dependent on the chemical processes occurring in and around the gut, aiding the cells and good bacteria that carry out the mechanisms can help overall health.

THE GASTROINTESTINAL PANEL IS INDICATED FOR PATIENTS WITH

  • Irritable Bowel Syndrome (IBS)
  • Chronic Constipation
  • Chronic Diarrhea
  • Intermittent Intestinal Pain
  • Mast Cell Disorder
  • Chronic Reflux
  • Recurrent Intestinal Infection
  • Numerous Food Allergies

Neurotransmitter Panel

The issues that accompany an imbalance of inhibitory and excitatory neurotransmitters can be exacerbated by specific genetic SNPs (single nucleotide polymorphisms) in neurotransmitter markers like COMT, MAO-A, MAO-B, and GAD1. Drugs (recreational or prescription), neurotoxins, stress, alcohol, poor diet, and caffeine can also fuel symptoms by encouraging these SNPs to further express themselves.

A NEUROTRANSMITTER IMBALANCE CAN CAUSE OR CONTRIBUTE TO THE FOLLOWING PROBLEMS

  • Depression
  • Anxiety
  • ADHD / ADD
  • Bipolar Disorder
  • Insomnia
  • Weight Issues
  • Hormone and Adrenal Dysfunction
  • Memory Issues
  • Migraines / Headaches

Neurotransmitter genetic testing shares what SNPs you have within the neurotransmitter markers.  This information allows us to recommend nutritionally support specific to those genetic shortcomings. Ultimately, neurotransmitter genetic testing lets doctors and their patients understand their underlying issues with neurotransmitter function and implement personalized solutions.

Detoxification Panel

This panel analyzes seven key SNPs in this area. Detoxification enzymes are responsible for clearing environmental chemicals and metabolic by-products from our body. Accumulation of theses chemicals and by-products can damage intracellular biochemical functions. Alternations in these systems can have a significant negative effect on the nervous system and immune system functions. These polymorphisms can results in decreased quality of life and even decreased lifespan.

Autophagy Panel

Autophagy is a natural physiological process that occurs to counteract the destruction of cells in the body. The term “autophagy” comes from the Greek words auto, meaning self, and phagy, meaning eating.  Like spring cleaning for the body, the self-eating process accumulates dead or senescent organelles and proteins, isolates them, dissolves what no longer serves the body, and recycles the remaining amino acids to be utilized elsewhere.  Autophagy is particularly important for cells that cannot regenerate easily and need to have long lifespans like cells in the kidney, liver, and pancreas. It’s crucial to overall health as it greatly helps in maintaining homeostasis.

When autophagy is disrupted, a buildup of dead, senescent, or even toxic organelles and proteins form. Cancer, autoimmune diseases, and neurological diseases like Alzheimer’s, dementia, Parkinson’s, ALS, and Multiple Sclerosis have been tied to increased mTOR activity. mTOR regulates cellular processes like growth, generation, survival, and autophagy. It also perceives energy levels, so when a cell is stressed or nutrient deprived, mTOR increases autophagy to find amino acids to fuel the body.  If mTOR is overactive, autophagy is usually bypassed to prioritize other activities, leading to an increase of buildup of byproducts. Some studies suggest that overactive mTOR activity is associated with decreased life span.  Without autophagy, cells undergo more stress, function less effectively, leading to quicker cell aging. Decreasing TOR activity can aid the up-regulation of autophagy, clearing cells of dysfunctional or dead cellular elements.

The innovative autophagy research of the last few years enables the scientific community and health care providers to reevaluate how they treat patients and what can improve with these new findings.  Some known natural autophagy stimulators are exercise, fasting, and high fat, low carb, low protein diets.  Exercise and 12 – 16 hours fasting can naturally stress cells into creating more energy through recycling existing amino acids in the cell by organically encouraging autophagy to kickstart.  High fat, low carb, low protein diets can encourage less mTOR activity, allowing for autophagy to take place.  mTOR inhibitors, a class of drugs that target mTOR, can also stimulate autophagy. These prescribed drugs like Rapamycin (sirolimus) may help those too ill to adopt natural stimulus or that need extra help because they effectively suppress the immune system in high doses, allowing mTOR activity to slow down and encourage autophagy to take place.  It’s important to have your autophagy activity tested before starting a prescribed mTOR inhibitors as they can suppress a healthy immune system, possibly leading to more health issues.

Pharmacogenomic Panel

Pharmacogenomic testing, otherwise known as PGx, refers to a type of genetic test to predict a patient’s likelihood to experience an adverse event or not respond to a given drug. Genetic variation in metabolism may result in high concentrations of drugs and an increased risk of adverse effects in slow metabolizers, which is important when using, for example, antidepressants or pain medication. The demand for pharmacogenomic testing is only expected to increase as researchers discover the potential of personalized medicine and the possibility of new drug development. Currently, the FDA includes black box, pharmacogenomic warnings on the labels of more than 200 medications, primarily mental health medications. A one-time cheek swab test lets providers know whether a patient has specific genetic variants to alert the provider of what drugs to avoid and prescribe to the patient.

Just as there are known drug-drug interactions, there are also known drug-gene interactions. Pharmacogenomics is the study of how a person’s genes affect their response to specific medications. It is a type of precision medicine that Dr. Bornfleth and GXSciences offers patients at an affordable cash price.